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26 April 2016 Optical probes for molecular-guided surgery: Using photomedicine to prevent recurrence in the surgical bed (Conference Presentation)
Bryan Q. Spring, R. Bryan Sears, Lei Z. Zheng, Zhiming Mai, Reika Watanabe, Elizabeth Villa, Tayyaba Hasan
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Proceedings Volume 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II; 96960B (2016) https://doi.org/10.1117/12.2213885
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
Residual tumor deposits missed by conventional treatments frequently seed local and distal recurrence utilizing a network of molecular signaling mechanisms. Beyond providing contrast for molecular-guided surgery, this talk will highlight new concepts in phototherapy to address residual cancer cells in danger zones of recurrence, including selective treatment of microscopic disease using molecular-targeted, activatable immunoconjugates, and photo-initiated release of multikinase inhibitors that suppress multiple modes of tumor escape using optically active nanoparticles. These new approaches support an expanded role for the use of light in fluorescence-guided surgery—for phototherapy and for focused drug release to maximize tumor debulking with suppression of disease recurrence.
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Bryan Q. Spring, R. Bryan Sears, Lei Z. Zheng, Zhiming Mai, Reika Watanabe, Elizabeth Villa, and Tayyaba Hasan "Optical probes for molecular-guided surgery: Using photomedicine to prevent recurrence in the surgical bed (Conference Presentation)", Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960B (26 April 2016); https://doi.org/10.1117/12.2213885
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KEYWORDS
Surgery
Tumors
Photomedicine
Phototherapy
Active optics
Cancer
Nanoparticles
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