Comparison of surface micro-structured and plasmonic all-fiber delivery probes for laser-induced thermotherapy of tumor cells

Riccardo Gassino; Papiya Dhara; Yu Liu; Hao Yu; Andrea Braglia; Massimo Olivero; Alberto Vallan; Guido Perrone

doi:10.1117/12.2211592

7 March 2016 Comparison of surface micro-structured and plasmonic all-fiber delivery probes for laser-induced thermotherapy of tumor cells

Riccardo Gassino, Papiya Dhara, Yu Liu, Hao Yu, Andrea Braglia, Massimo Olivero, Alberto Vallan, Guido Perrone

Author Affiliations +

Proceedings Volume 9702, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI; 97020I (2016) https://doi.org/10.1117/12.2211592
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

The paper compares two different approaches to design an innovative probe with optimized heated area for laser ablation of solid tumors: micro-patterning of the fiber delivery tip, and exploitation of the dissipation of plasmonic waves at the metal-dielectric interface. Both probes integrate a fiber Bragg grating for real- time monitoring of the obtained temperature increase to provide feedback to surgeons in practical applications. Experimental characterizations carried out using liver phantoms and ex-vivo porcine livers have demonstrated that both approaches can be used for the devised application, although further optimizations and tests are still necessary before clinical assessment.

Citation Download Citation

Riccardo Gassino, Papiya Dhara, Yu Liu, Hao Yu, Andrea Braglia, Massimo Olivero, Alberto Vallan, and Guido Perrone "Comparison of surface micro-structured and plasmonic all-fiber delivery probes for laser-induced thermotherapy of tumor cells", Proc. SPIE 9702, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI, 97020I (7 March 2016); https://doi.org/10.1117/12.2211592

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