Chiral liquid crystals as biosensing platforms

Mon-Juan Lee; Yu-Chien Sung; Yu-Cheng Hsiao; Wei Lee

doi:10.1117/12.2236774

23 September 2016 Chiral liquid crystals as biosensing platforms

Mon-Juan Lee, Yu-Chien Sung, Yu-Cheng Hsiao, Wei Lee

Proceedings Volume 9940, Liquid Crystals XX; 99400K (2016) https://doi.org/10.1117/12.2236774
Event: SPIE Organic Photonics + Electronics, 2016, San Diego, California, United States

Abstract

The texture observation has long been the core technique in liquid crystal (LC)-based bioassays. Its working principle stems from the dark-to-bright texture change induced by the interruption of the initially homeotropic alignment in nematic bulks or from the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. One of the drawbacks of this observational scheme, which requires a polarizing optical microscope, is the difficulty in quantitative analysis. In this invited paper, we report on our recent development of alternative optical biosensing techniques based on cholesteric LCs (CLCs) without the use of a polarizer. The increase in structural order in a vertically anchored CLC cell in the quasi-planar state provides a means to allow detection and quantification of the concentration of biomolecules immobilized on the interface between the mesophase and the surfactant DMOAP for LC vertical alignment.

Citation Download Citation

Mon-Juan Lee, Yu-Chien Sung, Yu-Cheng Hsiao, and Wei Lee "Chiral liquid crystals as biosensing platforms", Proc. SPIE 9940, Liquid Crystals XX, 99400K (23 September 2016); https://doi.org/10.1117/12.2236774

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