Safety study of tethered capsule endomicroscopy (TCE) pull back through long segments of the small intestine

Du-Ri Song; Mikayla F. Tinus; Patricia Grahmann; Jing Dong; Abigail Lee Gregg; David O. Otuya; Tara C. Lignelli; Evan Sevieri; Joseph A. Gardecki; Guillermo J. Tearney

doi:10.1117/12.2612623

7 March 2022 Safety study of tethered capsule endomicroscopy (TCE) pull back through long segments of the small intestine

Du-Ri Song, Mikayla F. Tinus, Patricia Grahmann, Jing Dong, Abigail Lee Gregg, David O. Otuya, Tara C. Lignelli, Evan Sevieri, Joseph A. Gardecki, Guillermo J. Tearney

Author Affiliations +

Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC119370O (2022) https://doi.org/10.1117/12.2612623
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We developed OCT-TCE devices with either guidewire or propylene glycol infusion tethers and tested pullback force and tissue damage over different distances of the small intestine in living swine. For all devices, the maximum force was below our safety threshold of 2N across intestinal lengths of 4m or less. At lengths > 4m, the force was > 4N for the infusion tube devices and > 5N for the guidewire devices, and the proximal intestine showed visible damage matching the tether shape. In conclusion, TCE may be safe for jejunal imaging but likely needs further improvement for ileum imaging in humans.

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Du-Ri Song, Mikayla F. Tinus, Patricia Grahmann, Jing Dong, Abigail Lee Gregg, David O. Otuya, Tara C. Lignelli, Evan Sevieri, Joseph A. Gardecki, and Guillermo J. Tearney "Safety study of tethered capsule endomicroscopy (TCE) pull back through long segments of the small intestine", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370O (7 March 2022); https://doi.org/10.1117/12.2612623

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