Mechanisms of photobiomodulation beyond cytochrome-C-oxidase: a perspective

Ann Liebert

doi:10.1117/12.2614324

7 March 2022 Mechanisms of photobiomodulation beyond cytochrome-C-oxidase: a perspective

Ann Liebert

Proceedings Volume PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; (2022) https://doi.org/10.1117/12.2614324
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The mechanisms of photobiomodulation, beyond the light interaction with cytochrome C oxidase has been the subject of increasing focus in the past few years, but have yet to be fully elucidated. Research into the non-mitochondrial mechanisms is warranted in order to more fully explain photobiomodulation mechanism in order to garner greater acceptance in the traditional medical non-photobiomodulation field. This is especially important since the currently accepted central mechanism of action, the absorption of wavelengths by cytochrome-C-oxidase and the subsequent release of ROS and production of ATP, is being increasingly questioned. A narrative literature review was conducted across photobiomodulation, photochemistry and photophysical scientific published literature to gather information to integrate potential novel mechanisms of photobiomodulation. This presentation will examine some of these potential mechanisms beyond cytochrome-C-oxidase, including opsins as potential photobiomodulation targets and the associated non-visual phototransduction pathways, the potential of photobiomodulation to produce a photophysical effect to induce mechanotransduction pathways, the potential of photons to interact with proteins in micro-oscillatory cellular effects, including interaction with the cytoskeleton and the role of internally produced light. An overarching hypothesis for an integrated mechanism of light pathways will be presented, with implications for treatment of chronic pain, and neurodegenerative disease, including Parkinson’s and Alzeimer’s diseases.

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Citation Download Citation

Ann Liebert "Mechanisms of photobiomodulation beyond cytochrome-C-oxidase: a perspective", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2614324

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KEYWORDS

Absorption

Acquisition tracking and pointing

Cytoskeletons

Medical research

Photochemistry

Photons

Proteins

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