Targeting photonanomedicines in cancer therapy: stromal, cellular and subcellular photomodulation

Girgis Obaid; Shazia Bano; Kimberley S. Samkoe; Imran Rizvi; Brian W. Pogue; David H. Kessel; Tayyaba Hasan

doi:10.1117/12.2624625

7 March 2022 Targeting photonanomedicines in cancer therapy: stromal, cellular and subcellular photomodulation

Girgis Obaid, Shazia Bano, Kimberley S. Samkoe, Imran Rizvi, Brian W. Pogue, David H. Kessel, Tayyaba Hasan

Proceedings Volume PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; (2022) https://doi.org/10.1117/12.2624625
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Photonanomedicines (PNMs) are photochemically-activated nanoscale drug delivery systems that play a niche role in photodynamic therapy (PDT)-based anticancer modalities. PNMs serve as versatile platforms for multi-agent delivery, spatiotemporally-controlled treatment induction and customization for tumor targeting. This work focuses on the systematic tuning of PNMs to achieve precision in tumor targeted photomodulation at three different scales: 1) stroma and interstitium, 2) proto-oncogenic cellular receptors, and 3) subcellular organelles (Figure 1). We show that photomodulation of tumors targeted at these three scales provides unique avenues to circumvent problematic barriers in drug delivery, treatment specificity, safety and tolerability, and treatment response.

Conference Presentation

Citation Download Citation

Girgis Obaid, Shazia Bano, Kimberley S. Samkoe, Imran Rizvi, Brian W. Pogue, David H. Kessel, and Tayyaba Hasan "Targeting photonanomedicines in cancer therapy: stromal, cellular and subcellular photomodulation", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2624625

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