Investigation of a method to extract confocal function parameters for depth resolved determination of attenuation coefficients using OCT in homogeneous, layered phantoms, and in-vivo human retina

Johannes Kübler; Vincent S. Zoutenbier; Arjen Amelink; Jörg Fischer; Johannes F. de Boer

doi:10.1117/12.2610228

7 March 2022 Investigation of a method to extract confocal function parameters for depth resolved determination of attenuation coefficients using OCT in homogeneous, layered phantoms, and in-vivo human retina

Johannes Kübler, Vincent S. Zoutenbier, Arjen Amelink, Jörg Fischer, Johannes F. de Boer

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Proceedings Volume PC11941, Ophthalmic Technologies XXXII; PC119410N (2022) https://doi.org/10.1117/12.2610228
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Accurate determination of the attenuation coefficients of retinal structures would allow for quantitative tissue characterization and can be calculated from OCT data. This requires compensating for the system’s confocal function. We present measurement series for extraction of the focal plane and apparent Rayleigh length from the ratios of OCT images acquired through a range of different focus depths. The optimal combination of focus depths is determined for intralipid and titanium oxide phantoms with different scatterer concentrations and the confocal-function-corrected attenuation coefficients are calculated. We further demonstrate good reproducibility in a multi-layered titanium oxide phantom and apply this method to in-vivo retinal data.

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Johannes Kübler, Vincent S. Zoutenbier, Arjen Amelink, Jörg Fischer, and Johannes F. de Boer "Investigation of a method to extract confocal function parameters for depth resolved determination of attenuation coefficients using OCT in homogeneous, layered phantoms, and in-vivo human retina", Proc. SPIE PC11941, Ophthalmic Technologies XXXII, PC119410N (7 March 2022); https://doi.org/10.1117/12.2610228

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KEYWORDS

Optical coherence tomography

Signal attenuation

Confocal microscopy

In vivo imaging

Retina

Titanium dioxide

Oxides

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