Selective IR inhibition can be reproduced by resistance heating

Junqi Zhuo; Chloe E. Weidrick; Yehe Liu; Michael A. Moffitt; E. Duco Jansen; Hillel J. Chiel; Michael W. Jenkins

doi:10.1117/12.2610130

7 March 2022 Selective IR inhibition can be reproduced by resistance heating

Junqi Zhuo, Chloe E. Weidrick, Yehe Liu, Michael A. Moffitt, E. Duco Jansen, Hillel J. Chiel, Michael W. Jenkins

Proceedings Volume PC11947, Optogenetics and Optical Manipulation 2022; PC1194706 (2022) https://doi.org/10.1117/12.2610130
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Infrared (IR) inhibition can induce selective heat block on small-diameter axons. We hypothesize that the selective IR inhibition effect can be reproduced by resistance heating via a heating cuff. We tested the hypothesis in vitro on the pleural-abdominal connective of Aplysia californica. The IR optical fiber, heating cuff, and a thermocouple were co-located to ensure both heating modalities induced a similar temperature increase on the nerve. Electrically stimulated compound action potentials were recorded and segmented to characterize the inhibition effect on different axonal subgroups. The dose-response curve showed that resistance heating can reproduce the selective IR inhibition effect.

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Citation Download Citation

Junqi Zhuo, Chloe E. Weidrick, Yehe Liu, Michael A. Moffitt, E. Duco Jansen, Hillel J. Chiel, and Michael W. Jenkins "Selective IR inhibition can be reproduced by resistance heating", Proc. SPIE PC11947, Optogenetics and Optical Manipulation 2022, PC1194706 (7 March 2022); https://doi.org/10.1117/12.2610130

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KEYWORDS

Resistance

Axons

Nerve

In vitro testing

Electrodes

Infrared radiation

Optical fibers

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