Magnetomotive micro-optical coherence tomography (μOCT) microrheology for probing cystic fibrosis mucus viscoelastic properties in-situ

Linhui Yu; Hui Min Leung; Courtney Petty; Daiqin Chen; Jung Soo Suk; Susan Birket; Steven Rowe M.D.; Guillermo Tearney M.D.

doi:10.1117/12.2605819

7 March 2022 Magnetomotive micro-optical coherence tomography (μOCT) microrheology for probing cystic fibrosis mucus viscoelastic properties in-situ

Linhui Yu, Hui Min Leung, Courtney Petty, Daiqin Chen, Jung Soo Suk, Susan Birket, Steven Rowe M.D., Guillermo Tearney M.D.

Author Affiliations +

Proceedings Volume PC11964, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX; PC119640F (2022) https://doi.org/10.1117/12.2605819
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We report the advancement of magnetomotive micro-optical coherence tomography (µOCT) technology for mapping the cystic fibrosis (CF) mucus viscoelastic properties in situ. We conducted pilot experiments in ex-vivo CF ferret trachea and wild-type swine trachea with a new magnetomotive system design. The system utilizes an electromagnet to drive magnetic nanoparticles with constant and uniform magnetomotive force in the field of view of µOCT. Preliminary results showed that the new system enhances individual magnetic micro-particle tracking and enables the measurement of the viscoelastic properties in different compartments of the mucus.

Conference Presentation

Citation Download Citation

Linhui Yu, Hui Min Leung, Courtney Petty, Daiqin Chen, Jung Soo Suk, Susan Birket, Steven Rowe M.D., and Guillermo Tearney M.D. "Magnetomotive micro-optical coherence tomography (μOCT) microrheology for probing cystic fibrosis mucus viscoelastic properties in-situ", Proc. SPIE PC11964, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX, PC119640F (7 March 2022); https://doi.org/10.1117/12.2605819

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