CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC11968 > Article
Presentation
12 May 2022 Optimisation of flow path parameters for enhanced sensitivity lateral flow devices
Alice Iles, Ioannis Katis, Peijun He, Panagiotis Galanis, Collin Sones, Robert Eason
Author Affiliations +
Proceedings Volume PC11968, Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics; PC1196804 (2022) https://doi.org/10.1117/12.2603880
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Lateral flow devices (LFDs) are widely used point-of-care (POC) diagnostics. The basic LFD design remains largely unchanged since their first development and this limits their use in clinical applications due to lack of sensitivity. To enhance this, we report the use of laser-patterned geometric control barriers, in the form of a constriction, that leads to a slower flow rate and smaller test zone area. This high sensitivity LFD (HS-LFD) achieved 62% increase in test line colour intensity for the detection of procalcitonin (PCT) and reduced the LOD from 10 ng/ml to 1 ng/ml with contrived human samples
Conference Presentation
© (2022) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Alice Iles, Ioannis Katis, Peijun He, Panagiotis Galanis, Collin Sones, and Robert Eason "Optimisation of flow path parameters for enhanced sensitivity lateral flow devices", Proc. SPIE PC11968, Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics, PC1196804 (12 May 2022); https://doi.org/10.1117/12.2603880
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Point-of-care devices
Polymers
Beam controllers
Biosensors
Diagnostics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top