Using diffuse reflectance spectroscopy to improve prostate cancer surgery outcomes.

Lotte M. de Roode; Joyce Sanders; Marcos A. S. Guimaraes; Pim J. van Leeuwen; Henk G. van der Poel; Lisanne L. de Boer; Theo J. M. Ruers

doi:10.1117/12.2647547

17 March 2023 Using diffuse reflectance spectroscopy to improve prostate cancer surgery outcomes.

Lotte M. de Roode, Joyce Sanders, Marcos A. S. Guimaraes, Pim J. van Leeuwen, Henk G. van der Poel, Lisanne L. de Boer, Theo J. M. Ruers

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Proceedings Volume PC12353, Advanced Photonics in Urology 2023; PC1235301 (2023) https://doi.org/10.1117/12.2647547
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Despite improved surgical techniques, the reported rate of positive surgical margins (PSM) after robotic-assisted laparoscopic prostatectomy remains as high as 20-40%. These PSM are associated with disease progression after surgery and should be avoided. Currently, there is no technique available to detect PSM intraoperatively. Diffuse Reflectance Spectroscopy (DRS) is proposed as a technique to detect tumor tissue at the surgical resection margin, intraoperatively. Over 800 measurements were performed on the prostate surface and, to mimic a PSM, on the cleaved prostate surface. A machine learning-based classification model was able to discriminate healthy tissue from tumor tissue with sufficient accuracy.

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Lotte M. de Roode, Joyce Sanders, Marcos A. S. Guimaraes, Pim J. van Leeuwen, Henk G. van der Poel, Lisanne L. de Boer, and Theo J. M. Ruers "Using diffuse reflectance spectroscopy to improve prostate cancer surgery outcomes.", Proc. SPIE PC12353, Advanced Photonics in Urology 2023, PC1235301 (17 March 2023); https://doi.org/10.1117/12.2647547

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KEYWORDS

Surgery

Tissues

Diffuse reflectance spectroscopy

Natural surfaces

Prostate

Prostate cancer

Tumors

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