Multifunctional coagulation profiling for cardiac surgical interventions at the point-of-care

Ziqian Zeng; Pablo Gonazalez Polanco; Zeinab Hajjarian Kashany; Diane M. Tshikudi; Seemantini K. Nadkarni

doi:10.1117/12.2656167

17 March 2023 Multifunctional coagulation profiling for cardiac surgical interventions at the point-of-care

Ziqian Zeng, Pablo Gonazalez Polanco, Zeinab Hajjarian Kashany, Diane M. Tshikudi, Seemantini K. Nadkarni

Proceedings Volume PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023; PC1235508 (2023) https://doi.org/10.1117/12.2656167
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Prolonged cardiopulmonary bypass (CPB) exposure and excessive anticoagulation during cardiac surgical procedures frequently cause acute bleeding. Here we investigated the accuracy and precision of a novel optical sensor, iCoaglab, that utilizes a small volume of whole blood to comprehensively monitor blood coagulation in patients. Our results showed coagulation metrics, activated clotting times (ACT), maximum clot stiffness (MA), and fibrinolysis were highly correlated with standard-reference tests. In conclusion, iCoaglab uniquely affords comprehensive profiling of whole blood coagulation, potentially enabling the capability to identify coagulation impairments and predict bleeding during CPB.

Conference Presentation

Citation Download Citation

Ziqian Zeng, Pablo Gonazalez Polanco, Zeinab Hajjarian Kashany, Diane M. Tshikudi, and Seemantini K. Nadkarni "Multifunctional coagulation profiling for cardiac surgical interventions at the point-of-care", Proc. SPIE PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023, PC1235508 (17 March 2023); https://doi.org/10.1117/12.2656167

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