Immune-modulatory effects of combination regimens with painless photodynamic therapy and pro-differentiating agents in a murine model of actinic keratosis

Sanjay Anand; Cheng-En Cheng; Lauren Heusinkveld; Edward V. Maytin

doi:10.1117/12.2651157

17 March 2023 Immune-modulatory effects of combination regimens with painless photodynamic therapy and pro-differentiating agents in a murine model of actinic keratosis

Sanjay Anand, Cheng-En Cheng, Lauren Heusinkveld, Edward V. Maytin

Author Affiliations +

Proceedings Volume PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; PC1235907 (2023) https://doi.org/10.1117/12.2651157
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Two different treatment modalities for skin cancer, topical 5-fluorouracil (5FU) and photodynamic therapy (PDT), have several non-overlapping mechanisms of action in addition to inducing long-term anti-tumor immunity mediated by cells of innate and adaptive immune systems. The particular type of PDT (painless, or p-PDT) uses aminolevulinic acid (ALA) and exposure to blue light in a non-apoptotic regimen resulting in lesion clearance mainly by immunological cell death. When combined, 5FU and p-PDT augment each other in multiple ways, including augmentation of anti-tumor immune activation, resulting in greater tumor reduction than possible with either modality alone.

Conference Presentation

Citation Download Citation

Sanjay Anand, Cheng-En Cheng, Lauren Heusinkveld, and Edward V. Maytin "Immune-modulatory effects of combination regimens with painless photodynamic therapy and pro-differentiating agents in a murine model of actinic keratosis", Proc. SPIE PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI, PC1235907 (17 March 2023); https://doi.org/10.1117/12.2651157

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