SPAD imagers in fluorescence-guided surgical navigation

Petr Bruza; Brian Pogue; Edoardo Charbon; Claudio Bruschini; Arthur Pétusseau

doi:10.1117/12.2650646

17 March 2023 SPAD imagers in fluorescence-guided surgical navigation

Petr Bruza, Brian Pogue, Edoardo Charbon, Claudio Bruschini, Arthur Pétusseau

Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC123610C (2023) https://doi.org/10.1117/12.2650646
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Fluorescence surgical navigation helps surgeons to see molecular information about tissue near the surface and distinguish malignancies from healthy tissue. It is possible to label tumors with specific fluorescent molecules, but not to easily see into tissue beyond microscopy limits of near a millimeter. Furthermore, the molecular targeting generally suffers from poor tumor-to-background contrast due to non-specific signal from healthy tissue. Both of these challenges can be addressed by time-resolved, single-photon sensitive imaging utilizing emerging SPAD sensors. Here we review current achievements in 3D depth sensing and functional imaging in vivo, and provide guidance for further design of surgical SPAD cameras. We hypothesize that the utility of surgical guidance will grow with the combination of new fast sensors and functional fluorescence imaging methods that utilize existing FDA-approved labels.

Conference Presentation

Citation Download Citation

Petr Bruza, Brian Pogue, Edoardo Charbon, Claudio Bruschini, and Arthur Pétusseau "SPAD imagers in fluorescence-guided surgical navigation", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC123610C (17 March 2023); https://doi.org/10.1117/12.2650646

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KEYWORDS

Luminescence

Imaging systems

Tissues

Sensors

Tumors

3D image processing

Natural surfaces

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