Self-propelled retrograde tethered capsule endomicroscopy (R-TCE) in the colon

Du-Ri Song; Tara C. Lignelli; Mikayla Tinus; Evan Sevieri; Patricia Grahmann; John J. McDaniel; Alissa A. Cirio; Paola L. Alarcon; Seamus S. Winters; Hamed Khalili; Abigail L. Gregg; David O. Otuya; Jing Dong; Adam Mauskapf; Joseph A. Gardecki; Andrew Thrapp; Guillermo J. Tearney M.D.

doi:10.1117/12.2652740

9 March 2023 Self-propelled retrograde tethered capsule endomicroscopy (R-TCE) in the colon

Du-Ri Song, Tara C. Lignelli, Mikayla Tinus, Evan Sevieri, Patricia Grahmann, John J. McDaniel, Alissa A. Cirio, Paola L. Alarcon, Seamus S. Winters, Hamed Khalili, Abigail L. Gregg, David O. Otuya, Jing Dong, Adam Mauskapf, Joseph A. Gardecki, Andrew Thrapp, Guillermo J. Tearney M.D.

Author Affiliations +

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC1236702 (2023) https://doi.org/10.1117/12.2652740
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We have developed a new self-propelled OCT imaging technology called retrograde Tethered Capsule Endomicroscopy (R-TCE) for colonic disease screening. We successfully demonstrated that the R-TCE device can be advanced over 1 meter in 5 swine colons in vivo. R-TCE with balloon pullback imaging enabled full circumferential OCT visualization of 95.94 % ± 0.13% of the colon wall. 3D reconstructed colon OCT images and 3D rendered flythroughs showed that R-TCE is feasible for OCT microscopic imaging of the entire colon in vivo. When translated to humans, this R-TCE technology may provide a less invasive and more efficient alternative to colonoscopy.

Conference Presentation

Citation Download Citation

Du-Ri Song, Tara C. Lignelli, Mikayla Tinus, Evan Sevieri, Patricia Grahmann, John J. McDaniel, Alissa A. Cirio, Paola L. Alarcon, Seamus S. Winters, Hamed Khalili, Abigail L. Gregg, David O. Otuya, Jing Dong, Adam Mauskapf, Joseph A. Gardecki, Andrew Thrapp, and Guillermo J. Tearney M.D. "Self-propelled retrograde tethered capsule endomicroscopy (R-TCE) in the colon", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC1236702 (9 March 2023); https://doi.org/10.1117/12.2652740

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