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Both disease and treatment of the cornea alter its microstructural and biomechanical properties. Previous work showed that dynamic light scattering (DLS) reflects changes in the cornea with respect to crosslinking treatment and post-surgical healing in vivo. However, due to the complex structure of the corneal stroma, the exact mechanisms which give rise to the DLS signal are unclear. This work attempts to determine the cause of DLS in the cornea by comparing the scattering signal under different conditions. The conclusions drawn from these studies inform the use of OCT-based dynamic light scattering measurements for corneal assessment.
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Brecken J. Blackburn, Matthew McPheeters, Michael Jenkins, William J. Dupps, Andrew M. Rollins, "Investigating corneal properties through temporal decorrelation in OCT images (Conference Presentation)," Proc. SPIE PC12393, Biomedical Applications of Light Scattering XIII, PC1239301 (16 March 2023); https://doi.org/10.1117/12.2650813