Systematic in vivo experiments at the Dresden platform for ultrahigh dose rate radiobiology

Elke Beyreuther; Michael Brand; Steffen Loeck; Josefine Metzkes-Ng; Jörg Pawelke; Ulrich Schramm; Joao Seco; Rita E. Szabo; Karl Zeil

doi:10.1117/12.2667906

8 June 2023 Systematic in vivo experiments at the Dresden platform for ultrahigh dose rate radiobiology

Elke Beyreuther, Michael Brand, Steffen Loeck, Josefine Metzkes-Ng, Jörg Pawelke, Ulrich Schramm, Joao Seco, Rita E. Szabo, Karl Zeil

Author Affiliations +

Proceedings Volume PC12583, Applying Laser-driven Particle Acceleration III: Using Distinctive Energetic Particle and Photon Sources; PC1258305 (2023) https://doi.org/10.1117/12.2667906
Event: SPIE Optics + Optoelectronics, 2023, Prague, Czech Republic

Abstract

The abovementioned authors are named on behalf of their respective groups. The recent rediscovery of the “Flash Effect” revived the interest in high and ultra-high dose-rate radiation effects throughout the radiobiology community, promising protection of normal tissue, while simultaneously not altering tumour control. Systematic preclinical studies at (modified) clinical accelerators resulted in a recipe of necessary beam parameters for the induction of electron Flash effect (doi:10.3389/fonc.2019.01563), whereas for protons the optimal parameter setting is still under investigation. Expanding the clinical parameter range the “Dresden platform for high-dose rate radiobiology” enables electron and proton experiments with dose rates of up to 109 Gy/s and more flexible beam pulse structures. The general applicability of these beams for radiobiological studies was proven with zebrafish embryos a simple but robust normal tissue in vivo model. Overall, the analysis of the induced radiation effects reveal a clear normal tissue protecting Flash effect for ultra-high dose rate electron and proton beams relative to their conventional beam delivery.

Conference Presentation

Citation Download Citation

Elke Beyreuther, Michael Brand, Steffen Loeck, Josefine Metzkes-Ng, Jörg Pawelke, Ulrich Schramm, Joao Seco, Rita E. Szabo, and Karl Zeil "Systematic in vivo experiments at the Dresden platform for ultrahigh dose rate radiobiology", Proc. SPIE PC12583, Applying Laser-driven Particle Acceleration III: Using Distinctive Energetic Particle and Photon Sources, PC1258305 (8 June 2023); https://doi.org/10.1117/12.2667906

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

In vivo imaging

Tissues

Radiation effects

Beam delivery

Keywords/Phrases

Search In:

Publication Years