Tumor irradiation in mice with a laser-accelerated proton beam

Florian-Emanuel Brack; Florian Kroll; Elke Beyreuther; Stephan Kraft; Josefine Metzkes-Ng; Jörg Pawelke; Marvin Reimold; Ulrich Schramm; Marvin Elias Paul Umlandt; Tim Ziegler; Karl Zeil

doi:10.1117/12.2665304

8 June 2023 Tumor irradiation in mice with a laser-accelerated proton beam

Florian-Emanuel Brack, Florian Kroll, Elke Beyreuther, Stephan Kraft, Josefine Metzkes-Ng, Jörg Pawelke, Marvin Reimold, Ulrich Schramm, Marvin Elias Paul Umlandt, Tim Ziegler, Karl Zeil

Author Affiliations +

Proceedings Volume PC12583, Applying Laser-driven Particle Acceleration III: Using Distinctive Energetic Particle and Photon Sources; PC1258309 (2023) https://doi.org/10.1117/12.2665304
Event: SPIE Optics + Optoelectronics, 2023, Prague, Czech Republic

Abstract

Recent oncological studies identified beneficial properties of radiation applied at ultra-high dose rates several orders of magnitude higher than the clinical standard of ~1 Gy/min. At the high-power laser source Draco, operated at Helmholtz-Zentrum Dresden-Rossendorf, a complete laser-driven proton research platform for diverse user-specific small animal models was demonstrated. Tunable single-shot doses up to around 20 Gy to millimeter-scale volumes on nanosecond time scales, equivalent to instantaneous dose rates of around 10^9 Gy/s. Spatially homogenized dose distributions tailored to the sample can be delivered with polychromatic proton beams of energies greater than 60 MeV, which have been provided with unprecedented stability and long-term reliability. These achievements allowed to successfully conduct the first radiobiological in vivo study using a laser-driven proton source. The pilot irradiation study was performed on human tumors in a mouse model, showing the concerted preparation of mice and laser accelerator, the dose-controlled, tumor-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumor growth delay. The prescribed homogeneous dose of 4 Gy was precisely delivered at the laser-driven source. The laser-based proton irradiation platform at the Draco PW facility enables systematic radiobiological studies within an unprecedented range of beam parameters and demonstrate a solution for minimally invasive volumetric dosimetry at ultra-high dose rates.

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Florian-Emanuel Brack, Florian Kroll, Elke Beyreuther, Stephan Kraft, Josefine Metzkes-Ng, Jörg Pawelke, Marvin Reimold, Ulrich Schramm, Marvin Elias Paul Umlandt, Tim Ziegler, and Karl Zeil "Tumor irradiation in mice with a laser-accelerated proton beam", Proc. SPIE PC12583, Applying Laser-driven Particle Acceleration III: Using Distinctive Energetic Particle and Photon Sources, PC1258309 (8 June 2023); https://doi.org/10.1117/12.2665304

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KEYWORDS

Laser irradiation

Tumors

Animal model studies

Dosimetry

High power lasers

In vivo imaging

Laser radiation

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