Decoupling noises generated by active forces from noises generated by a combination of passive and active stochastic forces on an optically trapped particle

Chong Shen; Simin Xia; H. Daniel Ou-Yang

doi:10.1117/12.2683979

5 October 2023 Decoupling noises generated by active forces from noises generated by a combination of passive and active stochastic forces on an optically trapped particle

Chong Shen, Simin Xia, H. Daniel Ou-Yang

Author Affiliations +

Proceedings Volume PC12649, Optical Trapping and Optical Micromanipulation XX; PC1264901 (2023) https://doi.org/10.1117/12.2683979
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States

Conference Poster

Abstract

Brownian motion reveals the mechanical environment of microscopic objects in thermal equilibrium. Mechanical fluctuations of microscopic objects, ubiquitous in living biological cells, are caused by a combination of thermal and biochemical forces; the latter are rich in spatiotemporal information of the forces and energies that drive such fluctuation. The question is how to distinguish the chemical driven from the thermal motion as they are often comparable in magnitude. This talk presents a proposed approach to decouple the motions produced by two independent stochastic forces by analyzing the motions of microscopic active particles individually confined by optical trapping. Applications of this approach to experiments are validated by comparison with Langevin-based numerical simulation. This approach applied to two distinctively driven active particles, one electrically and the other biologically, reveal surprising distinctive dynamics of these driven particles.

Citation Download Citation

Chong Shen, Simin Xia, and H. Daniel Ou-Yang "Decoupling noises generated by active forces from noises generated by a combination of passive and active stochastic forces on an optically trapped particle", Proc. SPIE PC12649, Optical Trapping and Optical Micromanipulation XX, PC1264901 (5 October 2023); https://doi.org/10.1117/12.2683979

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