Academia to industry translation of SLAM technology

Aneesh Alex; Kayvan F. Tehrani; Mantas Zurauskas; Matthew Durack; Reid Groseclose; Steve R. Hood; Stephen A. Boppart

doi:10.1117/12.3003121

13 March 2024 Academia to industry translation of SLAM technology

Aneesh Alex, Kayvan F. Tehrani, Mantas Zurauskas, Matthew Durack, Reid Groseclose, Steve R. Hood, Stephen A. Boppart

Proceedings Volume PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII; PC128210B (2024) https://doi.org/10.1117/12.3003121
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Simultaneous Label-free Autofluorescence Multiharmonic (SLAM) microscopy is a nonlinear multimodal optical imaging technique with sub-micron spatial resolution, enabling 3-D visualization and analysis of live cells, complex in vitro models, and tissues. SLAM microscopy detects NAD(P)H and FAD autofluorescence as well as second and third harmonic generation signals simultaneously from biological samples. It can be used for a wide range of applications in cell-to-clinic pharmaceutical research. To run proof-of-concept, longitudinal, and clinical studies of interest to GSK project teams, the GSK Center for Optical Molecular Imaging (COMI) was established in 2015. Based on promising results from these studies, GSK contracted with spin-out start-up, LiveBx, to design and develop the first portable SLAM microscope, and is currently being used for studies on-site at GSK. In this presentation, major milestones and challenges in translating the SLAM technology from academia to industry and key learnings from this process will be shared from multiple perspectives.

Conference Presentation

Citation Download Citation

Aneesh Alex, Kayvan F. Tehrani, Mantas Zurauskas, Matthew Durack, Reid Groseclose, Steve R. Hood, and Stephen A. Boppart "Academia to industry translation of SLAM technology", Proc. SPIE PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII, PC128210B (13 March 2024); https://doi.org/10.1117/12.3003121

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