Use of multiplexed optical detection techniques to elucidate anti-tumor immune responses in human basal cell carcinomas (BCC) treated with photodynamic therapy

Edward V. Maytin; Alan Shen; Lauren Heusinkveld; Jackson Hanna; Sanjay Anand; Judy Drazba; Claudia Marcela Diaz-Montero; Haidong Dong

doi:10.1117/12.3021791

13 March 2024 Use of multiplexed optical detection techniques to elucidate anti-tumor immune responses in human basal cell carcinomas (BCC) treated with photodynamic therapy

Edward V. Maytin, Alan Shen, Lauren Heusinkveld, Jackson Hanna, Sanjay Anand, Judy Drazba, Claudia Marcela Diaz-Montero, Haidong Dong

Author Affiliations +

Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC1282305 (2024) https://doi.org/10.1117/12.3021791
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) holds great promise as a treatment option for human basal cell carcinoma (BCC), the most common of all cancers. Recent evidence suggests that PDT is an immune-altering modality. Here we describe a clinical trial (NCT05020912) to examine the effects of ALA-PDT upon the tumor immune landscape within BCC tumors pre- and post-treatment, to better understand the nature of the tumor-infiltrating immune cells, and accompanying changes in systemic anti-tumor immunity. If better understood, such knowledge could be harnessed to improve therapeutic responses to PDT.

Conference Presentation

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Edward V. Maytin, Alan Shen, Lauren Heusinkveld, Jackson Hanna, Sanjay Anand, Judy Drazba, Claudia Marcela Diaz-Montero, and Haidong Dong "Use of multiplexed optical detection techniques to elucidate anti-tumor immune responses in human basal cell carcinomas (BCC) treated with photodynamic therapy", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC1282305 (13 March 2024); https://doi.org/10.1117/12.3021791

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