Investigating the dependency of dynamic optical coherence tomography signals on resolution and wavelength by experimental and simulation approaches

Shumpei Fujimura; Ibrahim Abd El-Sadek; Pradipta Mukherjee; Yiheng Lim; Lida Zhu; Rion Morishita; Yuanke Feng; Yoshiaki Yasuno

doi:10.1117/12.3005612

13 March 2024 Investigating the dependency of dynamic optical coherence tomography signals on resolution and wavelength by experimental and simulation approaches

Shumpei Fujimura, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiheng Lim, Lida Zhu, Rion Morishita, Yuanke Feng, Yoshiaki Yasuno

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128301E (2024) https://doi.org/10.1117/12.3005612
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

We investigate the dependency of dynamic optical coherence tomography (DOCT) signal on wavelength and resolution in two systems. One is 840-nm spectral domain OCT, and the other is 1310-nm swept-source OCT. For wavelength dependency, we made the resolution roughly the same among two systems by computationally reducing the axial resolution of 840-nm system. For resolution dependency, we compared LIV images with and without reduction of the resolution. In addition, we performed numerical simulation by modeling the intracellular scatterer dynamics by a diffusion. Experiment and simulation suggested that LIV is highly affected by the wavelength, where shorter wavelength gives higher LIV.

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Shumpei Fujimura, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiheng Lim, Lida Zhu, Rion Morishita, Yuanke Feng, and Yoshiaki Yasuno "Investigating the dependency of dynamic optical coherence tomography signals on resolution and wavelength by experimental and simulation approaches", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128301E (13 March 2024); https://doi.org/10.1117/12.3005612

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