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We proposed a neural network to generate volumetric dynamic optical coherence tomography (DOCT) from small-number OCT frames. In this study, we used a DOCT method (i.e., logarithmic OCT intensity variance; LIV) and it is applied to tumor spheroid samples. A U-Net-based NN model was trained to generate a LIV image from only 4 OCT frames. The NN-generated LIV was subjectively and objectively compared with conventional LIV images generated from 32 frames. The comparison showed a high similarity between the NN-generated LIV and the conventional LIV. This NN-based method enabled volumetric DOCT with only 6.55 s acquisition time.
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