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13 March 2024 Digital plasmonic nanobubble sensors for single molecule detection
Zhenpeng Qin, Tingting Zhang, Ye Gao, Chen Xie
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Proceedings Volume PC12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV; PC1283505 (2024) https://doi.org/10.1117/12.3014128
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Addressing the pressing need for rapid and sensitive infectious disease diagnostics, we introduce DIgitAl plasMONic nanobubble Detection (DIAMOND), an innovative strategy harnessing plasmonic nanobubbles generated through laser-induced nanoparticles. Using gold nanoparticles in an optofluidic system, DIAMOND enables compartment-free digital counting and homogeneous immunoassays, demonstrating respiratory syncytial virus detection at single RNA copy per microliter. This breakthrough technology offers single-nanoparticle detection, direct virus sensing at room temperature, and simplified liquid handling, establishing itself as a versatile platform for expedited and highly sensitive diagnostics, with the added benefit of achieving detection within just 10 minutes. Concurrently, our research advances plasmonic nanobubble generation by anchoring sub-10 nm AuNPs onto thiol-rich Qβ virus-like particles, significantly enhancing photocavitation and reducing laser fluency. In a significant step forward, we are expanding the horizons of DIAMOND, now enabling single protein detection at attomolar concentrations, representing a remarkable advancement in our capabilities.
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Zhenpeng Qin, Tingting Zhang, Ye Gao, and Chen Xie "Digital plasmonic nanobubble sensors for single molecule detection", Proc. SPIE PC12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV, PC1283505 (13 March 2024); https://doi.org/10.1117/12.3014128
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KEYWORDS
Plasmonics
Nanobubbles
Gold nanoparticles
Diamond
Diagnostics
Molecules
Sensors
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