CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12841 > Article
Presentation
13 March 2024 The effect of radiation therapy on the growth rate of prostate tumor spheroids studied with dynamic contrast line-field optical coherence tomography (LF-dOCT)
Stephanie Swanson, Keyu Chen, Saduni U. S. Sumithrarachchige Don, Ernest Osei, Kostadinka Bizheva
Author Affiliations +
Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC1284106 (2024) https://doi.org/10.1117/12.3005670
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Prostate cancer is the most prevalent cancer among Canadian men and is often treated with radiation therapy. Historically, cancer has been studied using 2D cell culture methods, but recently 3D cell culture methods like tumor spheroids have been become popular to better replicate the physiological environment of the body. We developed ultrahigh resolution line-field OCT (LF-OCT) technology and a dynamic OCT (dOCT) method to image tumor spheroids and identify areas of necrosis, for comparison with computer simulation. The LF-OCT system has sufficient spatial resolution to identify individual cells and capture the cellular level of activity while the dOCT algorithm can resolve the dynamic activity accurately. The study will be extended to investigate the spatial and temporal development of necrosis in PC3 prostate tumor spheroids after irradiation. These results will be used to inform and extend the model to an in vivo environment.
Conference Presentation
© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Stephanie Swanson, Keyu Chen, Saduni U. S. Sumithrarachchige Don, Ernest Osei, and Kostadinka Bizheva "The effect of radiation therapy on the growth rate of prostate tumor spheroids studied with dynamic contrast line-field optical coherence tomography (LF-dOCT)", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC1284106 (13 March 2024); https://doi.org/10.1117/12.3005670
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Tumors
Optical coherence tomography
Radiotherapy
Prostate
Radiation effects
Cancer
Computer simulations
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top