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13 March 2024 Locating aggressive cancer in intact human prostates ex-vivo using a translational needle photoacoustic sensing probe
Linyu Ni, Weikuan Lin, Amy Kasputis, Deborah Postiff, Todd M. Morgan, Aaron M. Udager, Jay Guo, Xueding Wang, Guan Xu
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Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284206 (2024) https://doi.org/10.1117/12.3001108
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Our previous investigations effectively employed an interstitial all-optical needle photoacoustic sensing probe on ex vivo tissue studies. In this study, our goal is to locate aggressive PCa within an intact prostate ex vivo using our latest version translational needle PA probe. Targeting specific tissue components, we utilized wavelengths of 1220nm, 1370nm, 800nm, and 266nm. Evans blue dye was injected at the measured positions for histopathology analysis. The acquired photoacoustic signals were analyzed using PASA, including spectrum slopes and midbandfits derived at all wavelengths. With the limited number of insertions, we were able to identify cancers in 3 out of 4 prostates. This non-invasive methodology holds considerable promise for future clinical applications.
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Linyu Ni, Weikuan Lin, Amy Kasputis, Deborah Postiff, Todd M. Morgan, Aaron M. Udager, Jay Guo, Xueding Wang, and Guan Xu "Locating aggressive cancer in intact human prostates ex-vivo using a translational needle photoacoustic sensing probe", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284206 (13 March 2024); https://doi.org/10.1117/12.3001108
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KEYWORDS
Prostate
Cancer
Photoacoustic spectroscopy
Principal component analysis
Prostate cancer
Tissues
Frequency response
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