Multispectral photoacoustic tomography of tumor with cancer cell targeting hypoxia probe

Tianqu Zhai; Jiho Song; Xueding Wang; Janggun Jo; Jae Won Chang

doi:10.1117/12.2692391

13 March 2024 Multispectral photoacoustic tomography of tumor with cancer cell targeting hypoxia probe

Tianqu Zhai, Jiho Song, Xueding Wang, Janggun Jo, Jae Won Chang

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284214 (2024) https://doi.org/10.1117/12.2692391
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Non-invasive assessment of aggressive tumors with high spatial resolution and specificity has been challenging. This study presents an application of multispectral photoacoustic tomography (MSPT) in tumor imaging, using a specially designed hypoxia-responding agent, NOx-JS013. The developed hypoxia probe, NOx-JS013, is reduced to JS013 under hypoxic conditions common in aggressive tumors, with a shifted absorption peak. Additionally, NOx-JS013 specifically binds with NCEH1, a characteristic enzyme highly expressed in aggressive tumor cells. The results from In-vivo experiments on aggressive and non-aggressive tumors demonstrate the feasibility of the MSPT hypoxia imaging using NOx-JS013 hypoxia indicator enhanced with aggressive cancer cell targeting ability.

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Citation Download Citation

Tianqu Zhai, Jiho Song, Xueding Wang, Janggun Jo, and Jae Won Chang "Multispectral photoacoustic tomography of tumor with cancer cell targeting hypoxia probe", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284214 (13 March 2024); https://doi.org/10.1117/12.2692391

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KEYWORDS

Tumors

Hypoxia

Photoacoustic tomography

Cancer

Tissues

In vivo imaging

Mouse models

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