Monitoring distribution of the therapeutic agent dimethyl sulfoxide (DMSO) with hyperspectral excitation-resolved near-infrared fluorescence imaging

Farouk Nouizi; Jaedu Cho; Chang-Seok Kim; Gultekin Gulsen

doi:10.1117/12.3005062

13 March 2024 Monitoring distribution of the therapeutic agent dimethyl sulfoxide (DMSO) with hyperspectral excitation-resolved near-infrared fluorescence imaging

Farouk Nouizi, Jaedu Cho, Chang-Seok Kim, Gultekin Gulsen

Author Affiliations +

Proceedings Volume PC12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII; PC128460J (2024) https://doi.org/10.1117/12.3005062
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Dimethyl sulfoxide (DMSO) is one of the most commonly used pharmaceutical drugs in life sciences. It has a wide spectrum of pharmacological effects, including anti-inflammatory effects, local analgesia, weak bacteriostasis and most importantly membrane penetration. We recently developed novel hyperspectral excitation-resolved near-infrared fluorescence imaging system (HER-NIRF) based on a continuous-wave wavelength-swept laser. In this study, this technique is applied for measuring the distribution of the therapeutic agent dimethyl sulfoxide (DMSO) by utilizing solvatochromic shift in the spectral profile of albumin-bound Indocyanine green (ICG). Phantom experiments are conducted to evaluate the performance of the HER-NIRF system. The results show that the distribution of DMSO can be visualized in the wide-field reflection geometry.

Conference Presentation

Citation Download Citation

Farouk Nouizi, Jaedu Cho, Chang-Seok Kim, and Gultekin Gulsen "Monitoring distribution of the therapeutic agent dimethyl sulfoxide (DMSO) with hyperspectral excitation-resolved near-infrared fluorescence imaging", Proc. SPIE PC12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII, PC128460J (13 March 2024); https://doi.org/10.1117/12.3005062

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KEYWORDS

Therapeutic agents

Fluorescence imaging

In vivo imaging

Near infrared

Permeability

Reflection

Skin

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