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13 March 2024 Quantitative analysis of reactive oxygen species produced by core-shell gold nanoparticles during radiation therapy
Peuli Nath, Negar Charchi, Diana Shvydka, Aniruddha Ray
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Proceedings Volume PC12859, Colloidal Nanoparticles for Biomedical Applications XIX; PC128590K (2024) https://doi.org/10.1117/12.3003201
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We present a method to improve the radiation-induced reactive oxygen species (ROS) generation from gold nanoparticles (AuNPs), within cancer cells and tissues. This involves coating the AuNPs with various biocompatible polymers and exposing them to X-ray irradiation in the therapeutic range. Under 6 MeV X-ray irradiation we observed ~250-300% enhancement in the production of ROS in presence of silica-coated AuNPs, compared to the controls. These findings emphasize the potential of polymer-coated AuNPs in enhancing the effectiveness of AuNP-mediated radiation therapy. By boosting the generation of ROS, these nanoparticles can improve the therapeutic efficacy of radiation therapy, particularly at low doses.
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Peuli Nath, Negar Charchi, Diana Shvydka, and Aniruddha Ray "Quantitative analysis of reactive oxygen species produced by core-shell gold nanoparticles during radiation therapy", Proc. SPIE PC12859, Colloidal Nanoparticles for Biomedical Applications XIX, PC128590K (13 March 2024); https://doi.org/10.1117/12.3003201
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KEYWORDS
Radiotherapy
Gold nanoparticles
Oxygen
Quantitative analysis
Tumors
X-rays
Cancer
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