A photoconvertible water-soluble-chlorophyll-binding protein of Chenopodium album as a contrast agent for photoacoustic imaging

Hannah Hayeon Kim; Victor T. C. Tsang; Bingxin Huang; Chi Kwan Chan; Terence T. W. Wong

doi:10.1117/12.3002060

13 March 2024 A photoconvertible water-soluble-chlorophyll-binding protein of Chenopodium album as a contrast agent for photoacoustic imaging

Hannah Hayeon Kim, Victor T. C. Tsang, Bingxin Huang, Chi Kwan Chan, Terence T. W. Wong

Author Affiliations +

Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620S (2024) https://doi.org/10.1117/12.3002060
Event: SPIE BiOS, 2024, San Francisco, California, United States

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Abstract

This work proposes developing a water-soluble-chlorophyll-binding protein (WSCP) from Chenopodium album plant species (CaWSCP) as a contrast agent for cancer targeting with photoacoustic (PA) imaging. CaWSCP exhibits red-shifted absorption, good solubility, and photoconvertible properties that can generate enhanced contrast images while integrated SpyTag and SpyCatcher system enables active targeting of cancer cells. In vitro and in vivo experiments demonstrate the non-cytotoxic nature of WSCP and validate the efficacy of the SpyTag-SpyCatcher system for cancer cell targeting. Moreover, in vivo imaging confirm the contrast-enhancing capability of CaWSCP, positioning it as a promising candidate for PA imaging in cancer diagnostics.

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Hannah Hayeon Kim, Victor T. C. Tsang, Bingxin Huang, Chi Kwan Chan, and Terence T. W. Wong "A photoconvertible water-soluble-chlorophyll-binding protein of Chenopodium album as a contrast agent for photoacoustic imaging", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620S (13 March 2024); https://doi.org/10.1117/12.3002060

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