Unlocking precision medicine in ophthalmology: achieving quantitative interoperability in retinal imaging to accelerate biomarker discovery and transform clinical trials

Eric Buckland

doi:10.1117/12.3026087

13 March 2024 Unlocking precision medicine in ophthalmology: achieving quantitative interoperability in retinal imaging to accelerate biomarker discovery and transform clinical trials

Eric Buckland

Author Affiliations +

Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620X (2024) https://doi.org/10.1117/12.3026087
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Quantitative imaging biomarkers are essential to advancing precision medicine within ophthalmology, providing objective insights into structural changes, disease progression, and treatment response. However, the path to their qualification and widespread adoption faces a significant hurdle: interoperability among imaging devices. In this presentation, we explore the role of industry standards and calibration phantoms in addressing the challenge of quantitative interoperability. We will review Maxwellian optics of the eye and implications for calibrating fundus cameras, OCT, and Adaptive Optics enabled retinal imaging systems. We explore how uniform and transparent calibrations can empower structural biomarker discovery and drive progress in ophthalmic clinical trials and personalized care.

Conference Presentation

Citation Download Citation

Eric Buckland "Unlocking precision medicine in ophthalmology: achieving quantitative interoperability in retinal imaging to accelerate biomarker discovery and transform clinical trials", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620X (13 March 2024); https://doi.org/10.1117/12.3026087

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