The extraordinary advances in quantum control of matter and light have been transformative for atomic and molecular precision measurements enabling probes of the most basic laws of Nature to gain a fundamental understanding of the physical Universe. The development of high-precision optical atomic clocks enables searches for the variation of fundamental constants, dark matter, violations of Lorentz invariance, and tests of gravity. Deployment of high-precision clocks in space will open the door to new applications, including precision tests of gravity and relativity, searches for a dark-matter halo bound to the Sun, and gravitational wave detection in wavelength ranges inaccessible on Earth, and others. I will give a broad overview of atomic clock applications on Earth and in space, focusing on searches for physics beyond the standard model of elementary particles. Several examples will be highlighted, including dark matter searches with atomic and nuclear clocks and new ideas for searches of physics beyond the standard model with quantum sensors in space. New ideas for detection of transient signals will be presented.
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