Non-invasive objective assessment of vulva skin health using diffuse reflectance spectroscopy

Keertana Vinod Ram; Dinish U.S.; Susan Logan; Ghayathri Balasundaram; Valerie Teo Xinhui; Ruochong Zhang; Steffie Silvani; Renzhe Bi; Cheng Kee Hua; Xia Xu; Giap Hean Goh; Mahesh Choolani; Malini Olivo

doi:10.1117/12.3022304

19 June 2024 Non-invasive objective assessment of vulva skin health using diffuse reflectance spectroscopy

Keertana Vinod Ram, Dinish U.S., Susan Logan, Ghayathri Balasundaram, Valerie Teo Xinhui, Ruochong Zhang, Steffie Silvani, Renzhe Bi, Cheng Kee Hua, Xia Xu, Giap Hean Goh, Mahesh Choolani, Malini Olivo

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Proceedings Volume PC13009, Clinical Biophotonics III; PC1300901 (2024) https://doi.org/10.1117/12.3022304
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Vulvar skin, distinct from other areas, undergoes changes due to aging, causing symptoms like dryness and itchiness. While much research focuses on facial or forearm skin, vulva skin properties are underexplored. This study uses an in-house developed fiber-based Diffuse Reflectance Spectroscopy (DRS) system to assess vulva skin changes in 100 women. This objective evaluation includes analyzing tissue chromophores—water, lipid, oxyhemoglobin, and deoxyhemoglobin providing insights into moisture content, lipid levels, oxygen saturation, and blood fraction. DRS, compared to invasive methods, achieved a 65% accuracy in estimating estrogen levels, suggesting its potential for objective diagnosis and monitoring of genitourinary skin conditions.

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Keertana Vinod Ram, Dinish U.S., Susan Logan, Ghayathri Balasundaram, Valerie Teo Xinhui, Ruochong Zhang, Steffie Silvani, Renzhe Bi, Cheng Kee Hua, Xia Xu, Giap Hean Goh, Mahesh Choolani, and Malini Olivo "Non-invasive objective assessment of vulva skin health using diffuse reflectance spectroscopy", Proc. SPIE PC13009, Clinical Biophotonics III, PC1300901 (19 June 2024); https://doi.org/10.1117/12.3022304

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KEYWORDS

Skin

Diffuse reflectance spectroscopy

Chromophores

Tissues

Blood

Body composition

Diseases and disorders

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