Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study

Valentina Quaresima; Marco Ferrari; Alessandro Torricelli; Lorenzo Spinelli; Antonio Pifferi; Rinaldo Cubeddu

doi:10.1117/1.1851512

1 January 2005 Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study

Valentina Quaresima, Marco Ferrari, Alessandro Torricelli, Lorenzo Spinelli, Antonio Pifferi, Rinaldo Cubeddu

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Journal of Biomedical Optics, Vol. 10, Issue 1, 011012 (January 2005). https://doi.org/10.1117/1.1851512

Abstract

The letter-fluency task-induced response over the prefrontal cortex is investigated bilaterally on eight subjects using a recently developed compact, eight-channel, time-resolved, near-IR system. The cross-subject mean values of prefrontal cortex oxygen saturation (SO2) were 68.8±3.2% (right) and 71.0±3.6% (left), and of total hemoglobin concentration (tHb) were 69.6±9.6 µM (right) and 69.5±9.9 µM (left). The typical cortical activation response to the cognitive task [characterized by an increase in oxyhemoglobin (O₂Hb) with a concurrent decrease in deoxyhemoglobin (HHb)] at each measurement point is observed in only four subjects. In this subset, the amplitude of the O₂Hb increase and HHb decrease is uniform over each prefrontal cortex area and comparable between the two hemispheres. These findings agree with previous studies using continuous wave functional near-IR spectroscopy and functional magnetic resonance imaging, therefore demonstrating the potential of a time-resolved spectroscopy approach. In addition, a significant increase in SO₂ levels was observed in the right (1.1±0.5%) compared to left side of the prefrontal cortex (0.9±0.5%) (P=0.005). A different pattern of cortical activation (characterized by the lack of HHb decrease or even increased HHb) was observed in the remaining subjects.

©(2005) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Valentina Quaresima, Marco Ferrari, Alessandro Torricelli, Lorenzo Spinelli, Antonio Pifferi, and Rinaldo Cubeddu "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," Journal of Biomedical Optics 10(1), 011012 (1 January 2005). https://doi.org/10.1117/1.1851512

Published: 1 January 2005

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