Spectrally resolving and scattering-compensated x-ray luminescence/fluorescence computed tomography

Wenxiang Cong; Haiou Shen; Ge Wang

doi:10.1117/1.3592499

1 June 2011 Spectrally resolving and scattering-compensated x-ray luminescence/fluorescence computed tomography

Wenxiang Cong, Haiou Shen, Ge Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 6, 066014 (June 2011). https://doi.org/10.1117/1.3592499

Abstract

The nanophosphors, or other similar materials, emit near-infrared (NIR) light upon x-ray excitation. They were designed as optical probes for in vivo visualization and analysis of molecular and cellular targets, pathways, and responses. Based on the previous work on x-ray fluorescence computed tomography (XFCT) and x-ray luminescence computed tomography (XLCT), here we propose a spectrally-resolving and scattering-compensated x-ray luminescence/fluorescence computed tomography (SXLCT or SXFCT) approach to quantify a spatial distribution of nanophosphors (other similar materials or chemical elements) within a biological object. In this paper, the x-ray scattering is taken into account in the reconstruction algorithm. The NIR scattering is described in the diffusion approximation model. Then, x-ray excitations are applied with different spectra, and NIR signals are measured in a spectrally resolving fashion. Finally, a linear relationship is established between the nanophosphor distribution and measured NIR data using the finite element method and inverted using the compressive sensing technique. The numerical simulation results demonstrate the feasibility and merits of the proposed approach.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Wenxiang Cong, Haiou Shen, and Ge Wang "Spectrally resolving and scattering-compensated x-ray luminescence/fluorescence computed tomography," Journal of Biomedical Optics 16(6), 066014 (1 June 2011). https://doi.org/10.1117/1.3592499

Published: 1 June 2011

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KEYWORDS

X-rays

Near infrared

Scattering

Photons

Computed tomography

Laser scattering

Luminescence

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