Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography

Qingliang Zhao; Chuanqing Zhou; Huajiang Wei; Yonghong He; Xinyu Chai; Qiushi Ren

doi:10.1117/1.JBO.17.10.105004

1 October 2012 Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography

Qingliang Zhao, Chuanqing Zhou, Huajiang Wei, Yonghong He, Xinyu Chai, Qiushi Ren

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Journal of Biomedical Optics, Vol. 17, Issue 10, 105004 (October 2012). https://doi.org/10.1117/1.JBO.17.10.105004

Abstract

Recent reports have suggested that spectral domain optical coherence tomography (SD-OCT) is a useful tool for quantifying the permeability of hyperosmotic agents in various tissues. We report our preliminary results on quantification of glucose diffusion and assessment of the optical attenuation change due to the diffusion of glucose in normal and adenomatous human colon tissues in vitro by using a SD-OCT and then calculated the permeability coefficients (PC) and optical attenuation coefficients (AC). The PC of a 30% aqueous solution of glucose was 3.37±0.23×10 −6 cm/s in normal tissue and 5.65±0.16×10 −6 cm/s in cancerous colon tissue. Optical AC in a normal colon ranged from 3.48±0.37 to 2.68±0.82 mm −1 and was significantly lower than those seen in the cancerous tissue (8.48±0.95 to 3.16±0.69 mm −1 , p<0.05 ). The results suggest that quantitative measurements of using PC and AC from OCT images could be a potentially powerful method for colon cancer detection.

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Qingliang Zhao, Chuanqing Zhou, Huajiang Wei, Yonghong He, Xinyu Chai, and Qiushi Ren "Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography," Journal of Biomedical Optics 17(10), 105004 (1 October 2012). https://doi.org/10.1117/1.JBO.17.10.105004

Published: 1 October 2012

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