Digital image correlation–based optical coherence elastography

Cuiru Sun; Beau A. Standish; Barry Vuong; Xiao-Yan Wen; Victor X. D. Yang

doi:10.1117/1.JBO.18.12.121515

17 December 2013 Digital image correlation–based optical coherence elastography

Cuiru Sun, Beau A. Standish, Barry Vuong, Xiao-Yan Wen, Victor X. D. Yang

Author Affiliations +

Journal of Biomedical Optics, Vol. 18, Issue 12, 121515 (December 2013). https://doi.org/10.1117/1.JBO.18.12.121515

Abstract

Optical coherence elastography (OCE) provides deformation or material properties, mapping of soft tissue. We aim to develop a robust speckle tracking OCE technique with improved resolution and accuracy. A digital image correlation (DIC)-based OCE technique was developed by combining an advanced DIC algorithm with optical coherence tomography (OCT). System calibration and measurement error evaluation demonstrated that this DIC-based OCE technique had a resolution of ∼0.6 μm displacement and <0.5% strain measurement in the axial scan direction. The measured displacement ranged from 0.6 to 150 μm, obtained via phantom imaging. The capability of the DIC-based OCE technique, for differentiation of stiffness, was evaluated by imaging a candle gel phantom with an irregularly shaped stiff inclusion. OCE imaging of a chicken breast sample differentiated the fat, membrane, and muscle layers. Strain elastograms of an aneurysm sample showed heterogeneity of the tissue and clear contrast between the adventitia and media. These promising results demonstrated the capability of the DIC-based OCE for the characterization of the various components of the tissue sample. Further improvement of the system will be conducted to make this OCE technique a practical tool for measuring and differentiating material properties of soft tissue.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Cuiru Sun, Beau A. Standish, Barry Vuong, Xiao-Yan Wen, and Victor X. D. Yang "Digital image correlation–based optical coherence elastography," Journal of Biomedical Optics 18(12), 121515 (17 December 2013). https://doi.org/10.1117/1.JBO.18.12.121515

Published: 17 December 2013

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY