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27 January 2017 Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters
Claudia Carrara Cotomacio, Luana Campos, Douglas Nesadal de Souza, Victor Elias Arana-Chavez, Alyne Simões
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Journal of Biomedical Optics, Vol. 22, Issue 1, 018003 (January 2017). https://doi.org/10.1117/1.JBO.22.1.018003
Abstract
Oral mucositis (OM) is a debilitating consequence of cancer treatment that could be treated with photobiomodulation therapy (PBMT); however, there is no consensus about its dosimetric parameters for OM healing. The aim of this study was to compare different PBMT protocols on OM treatment, through clinical and histological analysis. Thirty hamsters were used, in an induced model of OM by 5-fluorouracil (5-FU) and superficial scratching, in seven days of follow-up. The animals were divided into five groups: control (C), which received only anesthesia and chemotherapeutic vehicle; chemotherapy (Ch), which received anesthesia, 5-FU, and scratches; laser 1 (L1), the same as Ch group, PBMT 6  J/cm2 and 0.24 J (one point); laser 2 (L2), the same as Ch group, PBMT 25  J/cm2 and 1 J (one point); and laser 3 (L3), the same as Ch group, PBMT 4 points of 0.24 J and 6  J/cm2 each. The laser used has λ=660  nm, 0.04  cm2 of spot area, and 40 mW. The best PBMT protocol to maintain lowest OM levels compared to Ch group was L1, followed by L2 and L3. Our results suggest that the application mode of PBMT and the energy delivered per area could interfere with the OM healing.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Claudia Carrara Cotomacio, Luana Campos, Douglas Nesadal de Souza, Victor Elias Arana-Chavez, and Alyne Simões "Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters," Journal of Biomedical Optics 22(1), 018003 (27 January 2017). https://doi.org/10.1117/1.JBO.22.1.018003
Received: 31 October 2016; Accepted: 9 January 2017; Published: 27 January 2017
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KEYWORDS
Laser dentistry
Tissues
Cancer
Laser therapeutics
Animal model studies
Connective tissue
Laser tissue interaction
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