Comparable change in stromal refractive index of cat and human corneas following blue-IRIS

Kaitlin T. Wozniak; Sara M. Gearhart; Daniel E. Savage; Jonathan D. Ellis; Wayne H. Knox; Krystel R. Huxlin

doi:10.1117/1.JBO.22.5.055007

24 May 2017 Comparable change in stromal refractive index of cat and human corneas following blue-IRIS

Kaitlin T. Wozniak, Sara M. Gearhart, Daniel E. Savage, Jonathan D. Ellis, Wayne H. Knox, Krystel R. Huxlin

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 5, 055007 (May 2017). https://doi.org/10.1117/1.JBO.22.5.055007

Abstract

Blue intratissue refractive index shaping (blue-IRIS) is a method with potential to correct ocular refraction noninvasively in humans. To date, blue-IRIS has only ever been applied to cat corneas and hydrogels. To test the comparability of refractive index change achievable in cat and human tissues, we used blue-IRIS to write identical phase gratings in ex vivo feline and human corneas. Femtosecond pulses (400 nm) were focused ∼300 μm below the epithelial surface of excised cat and human corneas and scanned to write phase gratings with lines ∼1 μm wide, spaced 5 μm apart, using a scan speed of 5 mm/s. Additional cat corneas were used to test writing at 3 and 7 mm/s in order to document speed dependence of the refractive index change magnitude. The first-order diffraction efficiency was immediately measured and used to calculate the refractive index change attained. Our data show that blue-IRIS induces comparable refractive index changes in feline and human corneas, an essential requirement for further developing its use as a clinical vision correction technique.

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Kaitlin T. Wozniak, Sara M. Gearhart, Daniel E. Savage, Jonathan D. Ellis, Wayne H. Knox, and Krystel R. Huxlin "Comparable change in stromal refractive index of cat and human corneas following blue-IRIS," Journal of Biomedical Optics 22(5), 055007 (24 May 2017). https://doi.org/10.1117/1.JBO.22.5.055007

Received: 13 December 2016; Accepted: 8 May 2017; Published: 24 May 2017

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KEYWORDS

Cornea

Tissues

Refractive index

Diffraction

Diffraction gratings

Femtosecond phenomena

Eye

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