Effect of low-level laser therapy on tissue repair after dental extraction in rats administered zoledronic acid and dexamethasone

João Batista Blessmann Weber; Renata Stifelman Camilotti; Juliana Jasper; Liliane Cristina Onofre Casagrande; Fábio Luiz Dal Moro Maito

doi:10.1117/1.JBO.22.5.058001

13 May 2017 Effect of low-level laser therapy on tissue repair after dental extraction in rats administered zoledronic acid and dexamethasone

João Batista Blessmann Weber, Renata Stifelman Camilotti, Juliana Jasper, Liliane Cristina Onofre Casagrande, Fábio Luiz Dal Moro Maito

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Journal of Biomedical Optics, Vol. 22, Issue 5, 058001 (May 2017). https://doi.org/10.1117/1.JBO.22.5.058001

Abstract

Bisphosphonates (BPs) are being increasingly used for the treatment of metabolic and oncological pathologies involving the skeletal system. Because of the severity of the BP associated osteonecrosis of the jaws, the difficulties of treatment, and patient discomfort, additional support methods for their management are needed. Laser therapy has an easy handling, photobiostimulator effect on tissues healing, so it can be considered a preferred therapy. The aim of this study was to evaluate the influence of low-level laser therapy in the 685- and 830-nm wavelength in the healing process of the bone and soft tissues in rats under BP therapy [zoledronic acid (ZA)] and dexamethasone concomitantly that underwent a surgery for the extraction of upper molars. There were statistically significant differences in the clinical evaluation of the wound and the weight of the animals. Regarding the histological evaluation, it was possible to observe the different maturations of the healing stage between groups. The effect of drug therapy with ZA and dexamethasone in the bone tissue repair process induces osteonecrosis of the jaw in rats and slows down the healing process. In the laser groups, at the stipulated dosimetry, a positive influence on the bone and soft tissue repair process was observed.

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João Batista Blessmann Weber, Renata Stifelman Camilotti, Juliana Jasper, Liliane Cristina Onofre Casagrande, and Fábio Luiz Dal Moro Maito "Effect of low-level laser therapy on tissue repair after dental extraction in rats administered zoledronic acid and dexamethasone," Journal of Biomedical Optics 22(5), 058001 (13 May 2017). https://doi.org/10.1117/1.JBO.22.5.058001

Received: 24 January 2017; Accepted: 17 April 2017; Published: 13 May 2017

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