Study of drug diffusion rate by laser beam deflection technique

Mohanachandran Nair. S. Swapna; Madhu J. Anitha; Sankaranarayana Iyer Sankararaman

doi:10.1117/1.JBO.22.6.068001

7 June 2017 Study of drug diffusion rate by laser beam deflection technique

Mohanachandran Nair. S. Swapna, Madhu J. Anitha, Sankaranarayana Iyer Sankararaman

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 6, 068001 (June 2017). https://doi.org/10.1117/1.JBO.22.6.068001

Abstract

Drug administration is an unavoidable part of treatment. When a drug is administered orally or intravenously, it gets absorbed into the blood stream. The rate and efficiency of absorption depend on the route of administration. When a drug is administered through the oral route, it penetrates the epithelial cells of the intestinal mucosa. The diffusion of the drug into the blood stream depends on various parameters, such as concentration, temperature, and the nature of the mucous membrane. The passive diffusion of drugs is found to obey Fick’s law. Water soluble drugs penetrate the cell membrane through aqueous channel or pores. Hence, the study of diffusion of drugs into the water and finally into the blood stream is important. An attempt has been made to study the diffusion of the drug in water as 60% to 80% of human body is water. For the study of drug diffusion in water, a commonly used cough syrup of specific gravity 1.263 is used. It is found that the diffusion rate increases with the concentration of the drug.

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Mohanachandran Nair. S. Swapna, Madhu J. Anitha, and Sankaranarayana Iyer Sankararaman "Study of drug diffusion rate by laser beam deflection technique," Journal of Biomedical Optics 22(6), 068001 (7 June 2017). https://doi.org/10.1117/1.JBO.22.6.068001

Received: 31 March 2017; Accepted: 22 May 2017; Published: 7 June 2017

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KEYWORDS

Diffusion

Blood

Liquids

Plasma

Interfaces

Refractive index

Water

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