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8 March 2019 Parametric standing wave generation of a shallow reflection plane in a nonrigid sample for use in a noninvasive blood glucose monitor
Tomoya Kitazaki, Natsumi Kawashima, Naoyuki Yamamoto, Hiroyuki Nomura, Hanyue Kang, Akira Nishiyama, Kenji Wada, Ichiro Ishimaru
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Journal of Biomedical Optics, Vol. 24, Issue 3, 036003 (March 2019). https://doi.org/10.1117/1.JBO.24.3.036003
Abstract
When monitoring a moist sample using mid-infrared spectroscopy, its thickness must be <100  μm to avoid light absorption from the water. Therefore, we propose an ultrasonic-assisted mid-infrared spectroscopic imaging method that can generate a reflection plane at a depth of 100  μm from the surface of the sample by creating an ultrasonic standing wave. A frequency of 10 MHz is required to obtain an optical path length of 100  μm in biological samples. However, because biological samples generally have high compressibility, attenuation of ultrasonic waves at this frequency is significant. We use agar as a biological phantom and observe that a reflection plane is generated inside by ultrasonic standing waves using optical coherence tomography. It is found that when the sample is vibrated with an 800-kHz ultrasonic wave, a reflection plane is generated at a depth shallower than the theoretically predicted value. We believe that the reflection plane is generated by parametric standing waves, which are based on parametric effect. We detect the waveform distortion using an acoustic emission sensor and confirm the higher harmonics that generate the observed reflection plane using a fast Fourier transform.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Tomoya Kitazaki, Natsumi Kawashima, Naoyuki Yamamoto, Hiroyuki Nomura, Hanyue Kang, Akira Nishiyama, Kenji Wada, and Ichiro Ishimaru "Parametric standing wave generation of a shallow reflection plane in a nonrigid sample for use in a noninvasive blood glucose monitor," Journal of Biomedical Optics 24(3), 036003 (8 March 2019). https://doi.org/10.1117/1.JBO.24.3.036003
Received: 14 September 2018; Accepted: 19 February 2019; Published: 8 March 2019
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Cited by 7 scholarly publications.
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KEYWORDS
Ultrasonics
Reflection
Glucose
Blood
Absorption
Spectroscopy
Mid-IR
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