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31 October 2022 Hyperspectral imaging for tumor segmentation on pigmented skin lesions
Eleni Aloupogianni, Takaya Ichimura, Mei Hamada, Masahiro Ishikawa, Takuo Murakami, Atsushi Sasaki, Koichiro Nakamura, Naoki Kobayashi, Takashi Obi
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Journal of Biomedical Optics, Vol. 27, Issue 10, 106007 (October 2022). https://doi.org/10.1117/1.JBO.27.10.106007
Abstract

Significance

Malignant skin tumors, which include melanoma and nonmelanoma skin cancers, are the most prevalent type of malignant tumor. Gross pathology of pigmented skin lesions (PSL) remains manual, time-consuming, and heavily dependent on the expertise of the medical personnel. Hyperspectral imaging (HSI) can assist in the detection of tumors and evaluate the status of tumor margins by their spectral signatures.

Aim

Tumor segmentation of medical HSI data is a research field. The goal of this study is to propose a framework for HSI-based tumor segmentation of PSL.

Approach

An HSI dataset of 28 PSL was prepared. Two frameworks for data preprocessing and tumor segmentation were proposed. Models based on machine learning and deep learning were used at the core of each framework.

Results

Cross-validation performance showed that pixel-wise processing achieves higher segmentation performance, in terms of the Jaccard coefficient. Simultaneous use of spatio-spectral features produced more comprehensive tumor masks. A three-dimensional Xception-based network achieved performance similar to state-of-the-art networks while allowing for more detailed detection of the tumor border.

Conclusions

Good performance was achieved for melanocytic lesions, but margins were difficult to detect in some cases of basal cell carcinoma. The frameworks proposed in this study could be further improved for robustness against different pathologies and detailed delineation of tissue margins to facilitate computer-assisted diagnosis during gross pathology.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Eleni Aloupogianni, Takaya Ichimura, Mei Hamada, Masahiro Ishikawa, Takuo Murakami, Atsushi Sasaki, Koichiro Nakamura, Naoki Kobayashi, and Takashi Obi "Hyperspectral imaging for tumor segmentation on pigmented skin lesions," Journal of Biomedical Optics 27(10), 106007 (31 October 2022). https://doi.org/10.1117/1.JBO.27.10.106007
Received: 29 June 2022; Accepted: 10 October 2022; Published: 31 October 2022
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Cited by 7 scholarly publications.
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KEYWORDS
Tumors
Tissues
Skin
Image segmentation
Data modeling
Pathology
Tumor growth modeling
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