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14 December 2023 Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics
Cristianne Fernandez, Giles Blaney, Jodee Frias, Fatemeh Tavakoli, Angelo Sassaroli, Sergio Fantini
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Journal of Biomedical Optics, Vol. 28, Issue 12, 125004 (December 2023). https://doi.org/10.1117/1.JBO.28.12.125004
Abstract

Significance

Non-invasive optical measurements of deep tissue (e.g., muscle) need to take into account confounding contributions from baseline and dynamic optical properties of superficial tissue (adipose tissue).

Aim

Discriminate superficial and deep tissue hemodynamics using data collected with frequency-domain (FD) near-infrared spectroscopy (NIRS) in a dual-slope (DS) configuration.

Approach

Experimental data were collected in vivo on the forearm of three human subjects during a 3-min arterial occlusion or 1-min venous occlusion. Theoretical data were generated using diffusion theory for two-layered media with varying values of the reduced scattering coefficient (μs′) (range: 0.5 to 1.1 mm − 1) and absorption coefficient (μa) (range: 0.005 − 0.015 mm − 1) of the two layers, and top layer thickness (range: 2 to 8 mm). Data were analyzed using diffusion theory for a homogeneous semi-infinite medium.

Results

Experimental data in vivo were consistent with simulated data for a two-layered medium with a larger μs′ in the top layer, comparable absorption changes in the top and bottom layers during venous occlusion, and smaller absorption changes in the top vs. bottom layers during arterial occlusion.

Conclusions

The dataset generated by DS FD-NIRS may allow for discrimination of superficial and deep absorption changes in two-layered media, thus lending itself to individual measurements of hemodynamics in adipose and muscle tissue.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Cristianne Fernandez, Giles Blaney, Jodee Frias, Fatemeh Tavakoli, Angelo Sassaroli, and Sergio Fantini "Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics," Journal of Biomedical Optics 28(12), 125004 (14 December 2023). https://doi.org/10.1117/1.JBO.28.12.125004
Received: 11 July 2023; Accepted: 20 November 2023; Published: 14 December 2023
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KEYWORDS
Absorption
Adipose tissue
Muscles
Optical properties
Hemodynamics
Tissues
Near infrared spectroscopy
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