Feasibility of reduced-dose three-dimensional/four-dimensional-digital subtraction angiogram using a weighted edge preserving filter

Erick L. Oberstar; Michael A. Speidel; Brian J. Davis; Charles M. Strother; Charles A. Mistretta

doi:10.1117/1.JMI.4.1.013501

11 January 2017 Feasibility of reduced-dose three-dimensional/four-dimensional-digital subtraction angiogram using a weighted edge preserving filter

Erick L. Oberstar, Michael A. Speidel, Brian J. Davis, Charles M. Strother, Charles A. Mistretta

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Journal of Medical Imaging, Vol. 4, Issue 1, 013501 (January 2017). https://doi.org/10.1117/1.JMI.4.1.013501

Abstract

A conventional three-dimensional/four-dimensional (3D/4D) digital subtraction angiogram (DSA) requires two rotational acquisitions (mask and fill) to compute the log-subtracted projections that are used to reconstruct a 3D/4D volume. Since all of the vascular information is contained in the fill acquisition, it is hypothesized that it is possible to reduce the x-ray dose of the mask acquisition substantially and still obtain subtracted projections adequate to reconstruct a 3D/4D volume with noise level comparable to a full-dose acquisition. A full-dose mask and fill acquisition were acquired from a clinical study to provide a known full-dose reference reconstruction. Gaussian noise was added to the mask acquisition to simulate a mask acquisition acquired at 10% relative dose. Noise in the low-dose mask projections was reduced with a weighted edge preserving filter designed to preserve bony edges while suppressing noise. Two-dimensional (2D) log-subtracted projections were computed from the filtered low-dose mask and full-dose fill projections, and then 3D/4D-DSA reconstruction algorithms were applied. Additional bilateral filtering was applied to the 3D volumes. The signal-to-noise ratio measured in the filtered 3D/4D-DSA volumes was compared to the full-dose case. The average ratio of filtered low-dose SNR to full-dose SNR was 0.856 for the 3D-DSA and 0.849 for the 4D-DSA, indicating that the method is a feasible approach to restoring SNR in DSA scans acquired with a low-dose mask. The method was also tested in a phantom study with full-dose fill and 22%-dose mask.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Erick L. Oberstar, Michael A. Speidel, Brian J. Davis, Charles M. Strother, and Charles A. Mistretta "Feasibility of reduced-dose three-dimensional/four-dimensional-digital subtraction angiogram using a weighted edge preserving filter," Journal of Medical Imaging 4(1), 013501 (11 January 2017). https://doi.org/10.1117/1.JMI.4.1.013501

Received: 8 June 2016; Accepted: 12 December 2016; Published: 11 January 2017

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