Polarization-sensitive optical coherence tomography (PS-OCT) is used to investigate changes in fiber structures in the eyes of myopia, wet age-related macular degeneration (wAMD), and glaucoma patients. A depth-multiplexed fiber-based PS-OCT system is used to extract local optic axis orientations of birefringent structures in the eye locally in 3D in vivo. For healthy volunteers, birefringent structures include the retinal nerves, Henle’s fiber layer, and sclera. Scleral collagen architecture is observed to be altered in myopia patients. In wAMD patients fibrosis orientation and volume can be extracted using this technique.
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