THz-fingerprint coherent Raman spectroscopy at over 20,000 spectra/sec

Jorgen Walker Peterson; Matt Lindley; Julia Gala de Pablo; Kotaro Hiramatsu; Keisuke Goda

doi:10.1117/12.2607734

2 March 2022 THz-fingerprint coherent Raman spectroscopy at over 20,000 spectra/sec

Jorgen Walker Peterson, Matt Lindley, Julia Gala de Pablo, Kotaro Hiramatsu, Keisuke Goda

Proceedings Volume PC11971, High-Speed Biomedical Imaging and Spectroscopy VII; PC119710J (2022) https://doi.org/10.1117/12.2607734
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

High-speed broadband Raman spectroscopy (>1000 cm^−1 bandwidth) provides label-free molecular vibrational information with fine temporal resolution, making it valuable for biomedical applications such as vibrational imaging or detecting transient molecular dynamics. Current techniques for high-speed broadband Raman spectroscopy, such as Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) spectroscopy, can probe the Raman “fingerprint” region (500-1800 cm^−1), but lack sensitivity in the low-frequency or THz region (<200 cm^−1, <6 THz), preventing measurement of rich intermolecular vibrational information. Here we demonstrate a technique combining FT-CARS spectroscopy-like optical filtering with Sagnac interferometry for simultaneous acquisition of THz and fingerprint Raman spectra at 24,000 spectra/sec.

Conference Presentation

Citation Download Citation

Jorgen Walker Peterson, Matt Lindley, Julia Gala de Pablo, Kotaro Hiramatsu, and Keisuke Goda "THz-fingerprint coherent Raman spectroscopy at over 20,000 spectra/sec", Proc. SPIE PC11971, High-Speed Biomedical Imaging and Spectroscopy VII, PC119710J (2 March 2022); https://doi.org/10.1117/12.2607734

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