Laser-induced forward transfer for drug thin film printing

Christina Kryou; Ioanna-Maria Orfanou; Chrysoula Chandrinou; Zoi Kanaki; Marianneza Chatzipetrou; Constantin Tamvakopoulos; Apostolos Klinakis; Ioanna Zergioti

doi:10.1117/12.2621618

30 May 2022 Laser-induced forward transfer for drug thin film printing

Christina Kryou, Ioanna-Maria Orfanou, Chrysoula Chandrinou, Zoi Kanaki, Marianneza Chatzipetrou, Constantin Tamvakopoulos, Apostolos Klinakis, Ioanna Zergioti

Author Affiliations +

Proceedings Volume PC12147, Tissue Optics and Photonics II; PC121470J (2022) https://doi.org/10.1117/12.2621618
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Conference Poster

Abstract

The use of different 3D printing technologies for pharmaceutical manufacturing provides new opportunities for personalized medicine with adjusted doses in various shapes and structures. In this work, we present a novel manufacturing method of printing personalized dosage forms onto edible wafer papers as orodispersible thin films, targeting diseases such as types of cancer. Orodispersible films (ODFs) hold promise as a novel drug delivery method as they are easy to administer to young and older patients, bypass absorption by the digestive system and minimize the risk of partial loss of actives due to table crashing or imprecise liquid administration. LIFT technology could be used to “print” paclitaxel molecules on various surfaces that could be used as depot formulations. Laser-Induced Forward Transfer (LIFT) has been successfully applied in the nanosecond regime for the controlled transfer of paclitaxel solution onto the receiving substrates. Quantification studies of printed paclitaxel amount were determined by means of a Mass Spectrometry (MS)-based analytical technique. Furthermore, initial studies were performed where the printed paclitaxel wafer papers were used as orodispersible films (ODFs) on mice for oral mucosal drug delivery application, revealing encouraging results.

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Christina Kryou, Ioanna-Maria Orfanou, Chrysoula Chandrinou, Zoi Kanaki, Marianneza Chatzipetrou, Constantin Tamvakopoulos, Apostolos Klinakis, and Ioanna Zergioti "Laser-induced forward transfer for drug thin film printing", Proc. SPIE PC12147, Tissue Optics and Photonics II, PC121470J (30 May 2022); https://doi.org/10.1117/12.2621618

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