Light field two-photon microscopy for deep brain photostimulation and imaging

Yi Xue

doi:10.1117/12.2657216

30 March 2023 Light field two-photon microscopy for deep brain photostimulation and imaging

Yi Xue

Proceedings Volume PC12388, Adaptive Optics and Wavefront Control for Biological Systems IX; PC1238809 (2023) https://doi.org/10.1117/12.2657216
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

All-optical manipulation and recording of neural ensembles offer a non-invasive way to study the causal relationship between precise features of neural activity and specific aspects of sensation, cognition, and action. However, tissue scattering reduces the precision of two-photon multi-site photostimulation and limits the accessible depth. To correct multiple scattering, we propose to develop a new technique based on light field control for photostimulation and imaging of neural activity deep inside of the mouse brain.

Conference Presentation

Citation Download Citation

Yi Xue "Light field two-photon microscopy for deep brain photostimulation and imaging", Proc. SPIE PC12388, Adaptive Optics and Wavefront Control for Biological Systems IX, PC1238809 (30 March 2023); https://doi.org/10.1117/12.2657216

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