Imaging multi-scale dynamics in vivo with spiral volumetric optoacoustic tomography

X. Luís Deán-Ben; Thomas F. Fehm; Steven J. Ford; Sven Gottschalk; Daniel Razansky

doi:10.1117/12.2252701

3 March 2017 Imaging multi-scale dynamics in vivo with spiral volumetric optoacoustic tomography

X. Luís Deán-Ben, Thomas F. Fehm, Steven J. Ford, Sven Gottschalk, Daniel Razansky

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 100642K (2017) https://doi.org/10.1117/12.2252701
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Imaging dynamics in living organisms is essential for the understanding of biological complexity. While multiple imaging modalities are often required to cover both microscopic and macroscopic spatial scales, dynamic phenomena may also extend over different temporal scales, necessitating the use of different imaging technologies based on the trade-off between temporal resolution and effective field of view. Optoacoustic (photoacoustic) imaging has been shown to offer the exclusive capability to link multiple spatial scales ranging from organelles to entire organs of small animals. Yet, efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition and effective field of view. Herein, we introduce a spiral volumetric optoacoustic tomography (SVOT) technique that provides spectrally-enriched high-resolution optical absorption contrast across multiple spatio-temporal scales. We demonstrate that SVOT can be used to monitor various in vivo dynamics, from video-rate volumetric visualization of cardiac-associated motion in whole organs to high-resolution imaging of pharmacokinetics in larger regions. The multi-scale dynamic imaging capability thus emerges as a powerful and unique feature of the optoacoustic technology that adds to the multiple advantages of this technology for structural, functional and molecular imaging.

Conference Presentation

Citation Download Citation

X. Luís Deán-Ben, Thomas F. Fehm, Steven J. Ford, Sven Gottschalk, and Daniel Razansky "Imaging multi-scale dynamics in vivo with spiral volumetric optoacoustic tomography", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100642K (3 March 2017); https://doi.org/10.1117/12.2252701

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available